I've been riding the Tourguards for the past 3 years and have been extremely happy. I don't seem prone to flats, but I've only flatted twice with these in about 7k miles of mixed surface riding. I even carried a spare last year when one tire was aging, but it survived 3 days of rough, fast, loaded, trail bouncing and is still on the bike on the trainer this winter. I ride the 700x32, wet handling seems sure and they roll smoother then the comparable Continental they replaced.

I've heard complaints of weak sidewalls on the Panas, but not in my experience.