If the road is closed due to landslide, I'd consider riding through anyway. A few years ago, my friend George walked his bike over a landslide and he & his touring pal had all of Big Sur Hwy to himself. Just the thought of that makes me wish the Ebola virus would catch on on this continent...

And if it's just too ugly but you still need to get south, Highway 25 south out of Hollister is an interesting, uncrowded road, but access to water might be an issue.