According to a Bicycling magazine book I have, the best way to deal with saddle sores is to wipe down with alcohol before a ride, use some sort of chamois type cream and wipe down with alcohol after riding. Coincidently, I stumbled on this routine years ago and can attest to it's effectiveness. As for saddle comfort, as Little Darwin said, it's a highly personal thing. I had a Fizik that a riding friend loves and it didn't work for me. He traded a Selle Italia Flite he had for my Fizik and that saddle is perfect for me.