On one of my bike the transmission combo is -- Campagnolo 10 speed Ergo levers/DuraAce 10 speed cassette/Campagnolo 10 speed R/D and a KMC 10 speed chain. All Campagnolo trans. and all Shimano trans and all Sram trans. as a general rule work best when all the components match. Lately there are several using a Shimano cassette with a Sram trans to get a better feeling trans than with a Sram cassette. Many combos will work. just like there are several degrees of "will work". Mixing shifters & derailleurs & cassette's can be dicy and disastrous so if you have plenty of extra time on you hand try out a few different combos and go for a ride.