I've seen a narrow-spindle front road hub get well on the way to twist straight off in a build like that. Supposedly you can use the same length spokes as for an ordinary 3X build. It gives you a kinda-sorta radial look w/o quite that nasty load case on the flanges.
Feels a bit dodgy for a rear hub, as pedalling torque would have all spokes on one side lose a bit of tension simultaneously. But for a symmetrically dished wheel that migh still be manageable.