Initially, I only deflated weekly, but over the last few weeks, I've had to do it after every ride, as I have found numerous small pieces of glass deep into the rubber and they couldn't be seen unless the tyres were deflated.
This morning, I found 7 pieces of glass in the front and 2 in the rear - without deflating, I would have found only 1 in the front but both from the rear - so I feel justified at deflating after each ride. I ride past at least 4 pubs, and on a Monday morning (and weekend mornings), there is always plenty of broken glass in the kerbside lane.
It only takes another 5 minutes to pump up the tyres, so I don't see it as being a problem.