actually now that I think about it more the real answer is..................................
depends.
what model shifters, derailure, crankset etc. you are running. Some may be more problematic with spacing than others, if you are running a mixed speed groupo. As far as shifters go it shouldnt be a problem. Earlier shimano shifters were not double tripple specific, it should work you just end up with an extra trim position. 1st and second position and second and third position are the same spacing, just adjust the limit screws properly.