It is a matter of man and machine, and how they accommodate one another. Bicycles are designed to place all the weight in a region not designed by nature to support weight. To some extent, the biology can adapt and this will result in less sensitivity over time. The standing joke is if you are placing too much weight on the seat, you should get off the seat and just use it for balance. Everyone, however, sits fully on the seat.

The sits bones, extensions of the hip, are the weigh bearing skeletal bones, and seats have been designed that have no nose, but only contact the sits bones. They feel uncomfortable at first, and getting the friction right, and adjusting your legs to provide balance, takes a little time, ... but it is more naturally supporting. These seats are rarely used and more expensive - showing that usually people adjust to the commonly used seats, and this might mean they spend less time on their bikes unfortunately. If you are heavier you might be interested in a specially designed seat :

http://www.bikemania.biz/ProductDeta...gyWonderMark9B

I have no connection with this company, other than having purchased a seat from them. They are a tad expensive, but with them, you can go long, and be seated in comfort.