Well, I mean, if you're going to go with a modern group, go for it.

Older derailleurs and a kind of older crankset will work with modern STI's, at least from my experiences with Campy (I ride a crankset from 1990 and derailleurs from the same era with 2004-ish brifters). Also, you could go with a thread fork/headset/stem set up.