That is a nagging concern... I'm going to do some pretty extensive testing in this regard before we leave. My initial hypothesis is that it won't be a huge issue, although the bearings might need servicing a little sooner than they otherwise would. The QR skewers are supported by a semi conical bushing and a brass sleeve that closely matches the ID of the holes for the original axles... this allows the wheels to center up and align as the QR is tightened. The only lateral movement at the wheels comes from the slight flex in the frame. Also, there is minimal side loading like there would be if the wheels had to tilt in order to turn. It's an experiment!