I don't like them as well as the S2, but not so much because of the chamois although it has some issues. Mine are medium and the leg grippers are not as tight, nor are the legs as a general rule, so they tend to ride up my leg as I ride. The chamois has a little dimple in the middle and on a long ride, 70 mi or so, feels like someone is poking me with a nail up through the saddle. I probably won't buy another pair of S5, especially since I just purchased a pair of castelli body paint bibs, which are supremely comfortable, chamois seems almost to disappear, and very good leg compression. Also cheaper, about 230.