Originally Posted by cyccommute
On the other hand, when you get a flat - and you will- try getting the wheel off

You will have to carry a wrench big enough to both loosen and tighten the wheel nuts which means at least a 6 in. Cresent wrench. That's a lot of weight to be lugging around all the time.
I use these skewers (
http://www.nashbar.com/profile_morei...ku=8197&brand=) which use a 5mm allen key to loosen. If you're carrying a pump, tube, and tire irons, an allen key is pretty nominal. It's also useful on a lot of bolts on a typical bike.
One other consideration is that it's almost impossible nowadays to get quality wheels that don't use skewers.