Even if you replace the spokes with a disk you get the same thing the material of the disk at the bottom would not be in a s high of a tension as the material at the top.
If you had a rim, sufficiently strong enough to support the load without deformation, just in static, you could cut out the spokes on the bottom of the wheel with little effect. But if you were to flip that wheel 180 degrees it would collapse. Spokes are not strong enough in compression to support the load of the bike let alone my carcass.