Not all QR skewers are created equally. As far as new QR's, only Shimano and Campy use the internal cam design. External cam QR's don't have nearly as much clamping power as internal cam QR's. Back when pretty much all road bikes used horizontal dropouts, old school internal cam QR's were used and they held fine. Nowadays with almost all road and mountain bikes using vertical dropouts, almost all QR's (except Shimano and Campy) use the lighter weight external cam design. That's fine until you try and use an external cam QR in a horizontal dropout, it will almost always move in the dropout because of pedaling torque. We see this commonly at our bike shop, and solve the problem with a simple switch to a Shimano skewer or some old school skewer we have laying around.