My ride into work is usually the same each day - It's the most direct/fastest route, although not the most 'fun'. Usually I'm more concerned with getting into the office on time.
On the ride home, I tend to mix up my routes a bit more - I'm not in a rush, and it's nice to unwind a bit after working all day. If I'm in a rush, its the same route I take into work, and I'm home in 15 minutes. If I feel like a little bit longer but not too intense ride, I head over to a bike trail that takes me near home and I'm back in an hour.
If I'm feeling ambitious, well - I'd rather quickly go home, offload my work stuff, change into more cycling clothes and head out for the evening.