On my current bike I'm running with the 105's and triple up front. I find that most of the time on flats and rollers i'm shifting over a couple of gears at a time to get to the most comfortable gear so I probably use maybe half of the gearing combo's available if that. But with that said, I might not find those sweet spots running an 8 or 9 spd cassette so it is nice to have all the choices afforded with the 10spd rear.