I think he means that if she doesn't like cycling after 34-ish years of trying (since she was 5), that she never will.
She's barely tried though - Our bicycles when we were kids were horrid things from J.C. Penny's. I had the advantage of having friends that rode better bikes, so I knew what I was missing, and when I was coming up on my 14th birthday (1983) I went bike browsing in several LBS's. I really lusted after a Univega Viva Sport in the shop but flatly knew that $230 was out the question ($230 in 1983 was about the same as $900 today), and settled on a Giant-built Schwinn Traveler. I hit my parents up for it and was denied, but a week later they told me they'd go halves on it with me if I could raise the money. I worked my ass off mowing lawns for a couple of months, and just before my birthday my grandmother asked me how much I was short - she gave me the last $25 I needed to come up with my half.
In short, I knew what I was missing and went for it. My sister never liked her Penny's POS and never did. She got a hand-me-down from my grandmother in her late teens that was also a department store POS, and she hated that... I think she's ridden one or two bikes since then, all of them junk. She just doesn't know what she's missing.
I'll get her on a bike if it kills me.