I've been running Michelin Pro 3's with standard tubes on my Ksryium SSC SL's. They've been fine, and I've liked them. When the rear recently wore through, I replaced the Michelins with Continental Grand Prix 4000S tires and Michelin AirComp Ultra Light tubes. Wow! What a difference! I put them on my Scott Addict R3 today, rolled down the drive, and figured it would take some riding before, or if, I noticed any difference. Within about 3 pedal strokes, the increase in suppleness was very evident. The improvement was quite welcome on the local chip seal that makes up most of my rides.

I was very careful talc-ing the tubes and installing the tubes and tires. I was going to try some of the latex tubes, but based on the feel of the ultra lite butyls, I'll stick with these for now.

BTW, the Pro 3's wore through the tread in the middle of a 100 mi. ride with over 6K ft. of climbing. I was a little nervous on the downhills after I noticed that I was getting wear spots down to the casing.