Road frames are very strong... they have to handle impacts at much higher speed and are subject to some massive torque input at the crank and they simply have less tyre clearance than cross bikes.
If you are really going to be riding through pothole infested streets and doing a lot of curb hopping you need to focus on wheel quality and durability and for that I ride a converted steel framed mtb as the 0 dish 26 inch wheels (fixed drive) are hella strong.
My hybrid has hand built touring grade wheels and these have never needed to see a spoke wrench or be adjusted and they have been subjected to some decent abuse.
I also run a set of cross wheels with higher volume tyres on my hybrid and these have thousands of urban and off road miles on them and are still straight and free of dents / damage.