Every case is unique, but in general I don't believe it will be much of a limitation.
Sid Ferris wore a patch over his missing left eye while he set British distance-in-24-hours, time-to-1000-miles, Edinburgh-to-London and the Land's End-to-John O'Groats records in the late 1930s.
Mr. Ferris' end-to-end record stood for 20 years.
tcs