I've used my timbuk2 for over a year now, holding upwards of 80lbs in it with no issues aside from the strap doing a good number on my neck/chest.

Timbuk2's greatest issue is their strap being stright up, and not at an angle...this causes all kinds of ergonomic issues. I found the strap adjustment clutch to be stong enough...key is to adjust it while there is little tension on the main strap.

As far as pockets, mine has 4 inner pockets, and two outer, although those are hidden by hte flap. One of theouter is a zipper type.

Keep in mind Timbuk2's are mostly custom....you choose how you want it built, and pay accordingly.

Next time around I won't buy Timbuk2 though due to the ergonomic issues alone.