Morning route is almost always the same, partly because it's my daily time-trial, partly because I need to get to work. Smelling the Hostess bakery on Dexter every morning is a little rough though :-)
Ride home will vary alot depending on how far I want to ride, how much time I have, how bad the headwinds are coming off the water, and how I feel generally. My house (near Husky Stadium) and work (central Downtown) locations are great because I can change easily without feeling like I'm backtracking.