Most riders seem to prefer a smaller frame: less weight, stiffer, [allegedly] better handling... ...but I suspect it's more because we all want to look more like the TdF thoroughbreds.

Me (6'2"), I prefer to stretch out on a big 63cm (or in the case of my Schwinn, 25-inch) frame and just a 90mm stem. I've noticed that the bike does tend to waddle back & forth more with the 110mm stem installed, but this only increases your mileage, so it's a win-win.