It depends on how fussy you are about ride characteristics and how bad you want to avoid flats. I like a tire with a lively ride and am kind of fussy about extra weight especially on the wheels, as a result I wouldn't consider them. I did try them and took them off after a couple hundred miles.
The Pluses are very flat resistent, but are also very heavy (literally twice as heavy as many other tires in the same size).
To me fixing a flat once in a while isn't a big deal and a lively ride is a joy, so I ride on a light tire with a flexible sidewall and thin inner tubes with no liners.