Yeah, it doesn't matter if I'm in the drops or on top, it's awkward either way, and requires rotating my hands all the way around, it's just worse in the drops. Going to the big ring is a really long throw, and going down to the short ring is a double "click" (which I'm learning is the shifter skipping the non-existent middle gear) and it's the second click that gets me. Similar issue for the back gears, it's just a little better.
As I mentioned earlier, it doesn't help that the Tiagra shifters are really clunky and imprecise and feel like they're made entirely of plastic. I know some people ride them for years and think they're fine, but IMHO they're crap. I don't understand why they would put this group on a women's specific bike. I would have paid $1-200 more for 105 or the ST-R600 shifters made for a double when I bought it.