I'm running 52-39-26 in the front and 11-34 in the back. Ultegra FD and XTR RD. Only problem I've had is shifting up too much in the granny ring before grabbing the middle ring. Then the RD sort of collapses, and the middle ring can't pull chain. But if I don't do that, everything works fine. I'm switching to a 12-34 to get better midrange gear options.