I used to be a runner and took up cycling because I kept getting injured.

I tried the "seat as high as you can go without rocking your hips" school of positioning and had more knee problems. Lowering it to what's more traditional for cyclists works a lot better, both for injury prevention and making power. I'm real close to the LeMond formula now. I set the setback by balancing my quads and glutes, and it's reasonably far back, like 2cm (I'm tall so that's not as much as it would be for shorter riders).

I think there's a reason why experienced cyclists (i.e. pro racers) all have a similar fit, and going way out of that model is probably going to cause injury and/or make you slower than you'd be with a "normal" fit. That's for road riding, triathletes and TT racers have somewhat different parameters for their fit.