I just got a new bike(Fem Quick 3) and am having neck issues as well. The flat-bar it came with had a 20mm rise. I replaced that with one that had 30mm rise and a bit more backsweep. That took care of the wrist angle feeling wrong. Also tipping the saddle back slightly helped take even more weight off the hands. But then my neck started hurting! Maybe I am still too stretched out..so lowered the saddle next. Will take a ride to see how that works. The next step is a 40mm riser handlebar-but I know I will probably have to replace cables. Maybe an adjustable stem! I have written to cannondale and see what they recommend. Maybe there is a shorter stem I can use. Then I begin to wonder how much is just- the over 50 part? Perhaps we can have a special sticky called "Tweak my Ride".
If you have a visor,
take it off. This can help markedly.
Also, one needs to learn to
tuck your chin back into your chest , instead of stretching your neck forward and back.
Good luck.