Originally Posted by
auchencrow
Thicker tubes add weight and afford little protection from flats. It's like putting shingles on the INSIDE of your roof to prevent leaks.
Kevlar belted tires (Such as panaracer's pasella Tour-Guards) are a better way to prevent thorns and such from getting in.
Sure, but the OP is mainly looking to prevent the gradual loss of air due to diffusion through the tube rubber. Thicker tubes clearly do have an advantage there although 'thorn-proof' tubes are generally only thicker on the outer side and not on the side toward the rim. Also make sure you get the tubes in a wide size so they aren't stretched when inflated inside the tire.
Not clear what the OP is using to inflate the tire if he gets a flat. If it's CO2 then note that it diffuses through rubber much faster than the N2 and O2 in air, so after using it he should deflate the tire and refill with air to minimize gradual pressure loss.