The majors are all great. I personally ride SRAM (Red at $1100 pre TdF 09 sweep). For my second choice, I would like to try 11-speed Campy or Shimzo DA Di2. You can't go wrong with any of these. Shimzo mech, you have to push your brake levers to go to bigger gear, I'm not interested. I'm not saying it's a bad idea, but I like shifting with shifters, not brake levers. it's a personal thing. I grew up with Campy REcord down-tube friction shifters. At the time, early 60s, production overseen by Tulio, they were waay better then anything else out there. Unfortunately he died. He was a genius. I've ridden a lot of Shimzo stuff, used their fishing reels, spinning and blue-water fishing. They make very good stuff.