Originally Posted by
B. Carfree
The Campy instruction booklet I have recommends doing the adjustment with the chain off, so that's the way I do it. The top pulley has a little play that can interfere with my assessment of the alignment with the chain on, so it ends up being faster for me to just remove the chain.
Good to know that I'm not being an idiot.

If you've got to break out the chain tool it's probably not worth it but if you've got a power link (or equivalent) you might as well give your chain a good cleaning while you make your adjustments.