I do. I have a small and a large. The small is my everyday bag. My 13" MBP does not fit in the slash pocket, but does fit in the main compartment. I don't carry clothes with me, just my rain jacket. I only ride a mile each way and I just bike in work clothes. Sometimes I leave shoes at my office. The large is my grocery run bag. It's big enough to carry a couple of bags of groceries. I like the fact that I can take it into the store with me.

I would not want to try to fit all that you want to carry in the small. The large is very large, but suits my purpose well. I suggest the medium.

I love both bags, they are well made and comfortable to wear.