Wheels will be a the concern I think regardless. When you are our size, it's simply a fact. I've had great luck staying with 32 - 36 spoke hand built rims (700C). Chances are regardless you might have to upgrade. You can simply get a new rear handbuilt to keep costs down. I did on my Trek & it worked fine. 2200 is considered "entry level" for road racing. However, that being said, they function great and are night & day compared to "entry level" shifters on a hybrid.