Use Stan's sealant in the tires, use soapy water on the tire's bead when you initially inflate it, get access to an air compressor for initial inflation. Once done, you can top the tires off with a floor pump as needed, should be about the same as a tire with tubes in that regard. You'll be able to run very low pressures without pinch flat worries, get better traction and improve ride quality. The sealant will take care of small punctures as well. It's common to run pressures in the 20-30psi range. The advantages are pretty much limited to off road riding, so if you use the bike on pavement much, just stick with tubes. If you prefer pressure of 40+ pounds, I don't recommend tubeless (talking mtb tubeless here).