Are there any significant differences in fit or handling when using a shorter stem and longer reach handlebar vs a longer stem and shorter hb reach?

For instance, changing from a 100mm stem and 100mm reach hb to a 120mm stem and 80mm reach hb?

I can see that the longer stem will add to the reach when riding on the tops. Also, there would be less drop in the drops, since short reach handlebars usually have less drop a well.

Would anything else be affected?