Depends on the individual I guess.
I've not ridden my bikes much with a pack. But I've ridden a whole lot of motorcycle with one.
I zip-tied a milk crate to my dual sport's luggage rack so I wouldn't have to wear a pack anymore.
Might look a little silly, but it's a night/day difference.
I even had the pack adjusted so most of the weight of it was on the seat behind me.