Originally Posted by
Peptidoglycan
When the tire is inflated there is a dip in its shape where the patch might be( don't remember exact location). Could a upside down patch cause this to happen or is the tire/tube just not set right?
This is normal, and has nothing to do with the patch being upside down. If it's holding, and it looks well bonded, I wouldn't worry about it.
Edit: This is only normal if by tire you really mean tube. (see Kimmo, next post)