The father-in-law's running 1.5" slicks and trekking bars on his F4. He travels ultralight, and packs all he needs into two rear panniers and a handlebar bag. And he's retired, so he'd definitely living the dream.
My bike's got Nokian Extreme 296's mounted for the winter, been riding on studs since mid-October. In the summer I run Schwalbe Big Apples, big fat slicks.