Have a qualified lbs person help with this. And/or:

Fiddle some with the saddle position. Easy to do and cost nothing. Nose down is bad if you're not stetched out.
Double wrap the bar for cushioning and better ergonomics.
Raise the bar to just below or even with the saddle to reduce pressure on your hands and wrist.
Switch hand positions often.
Add aero bars for another comfortable, aerodynamic position where there is no hand/wrist pressure.

Good luck.