My shoes are a size 11EE and find that the pedals/toe clips solution that works best are MKS touring pedals w/ Nitto size L clips. I usually have the strap at just about as wide as it can go. I also have sewn V-O leathers on just about all of the clips on the fleet as I've found that really reduces hot spots on my feet. Still, I prefer SPD and have that system on bikes I'll use for longer rides.

Neal