For 53-11's question, I cannot tell any, but lately I use ultragatorskin tires and they are probably stiff enough to mask any difference. I would really think that the stiffness of the tire is 10X at least that of a tube. I doubt that a difference would be noted. That being said, one of the most supple tubes (and easy to patch) that I have used was a Colorado Cyclist sold item that I believe was "Torelli"...but I could not feel any ride diff. For rolling resistance, you are discussing a function involving dissipation of work. I would imagine that if very much were dissipated by the tube, it would overheat. The tire can dissipate heat via convection, conduction, and radiation. The tube is kind of stuck and I doubt that this mode amounts to anything. So my armchair engineering says NAW, but hey, YMMV