Never experienced that YET !
I ride most of the time in the big wheel and in about 4 gears on the cassette....with about 80% of the time in one gear.....have found that I can only get about 6,000 miles (3 chains) on a cassette before the 80% gear is worn to the point that shifts start slipping.......just a bad habit on my part , I certainly know better than that....