Originally Posted by Rich vSB
You may run into issues if the change of crank altered the distance of the chainrings or because you are running a significantly smaller large ring (44 vs 52).
You run into bigger issues if the spindle is longer or shorter than what's speced for the new crank. If the spindle is so long the dreailer can't reach the big ring,no amount of fiddling or adjusting will cure it.