Many MAVIC hubs require a MAVIC spacer approximately 2 mm thick. If you are running a 10-speed Shimano cassette with that type of MAVIC hub you will need both spacers, the MAVIC 2mm and the Shimano 1 mm.
If you use the low limit screw to move the derailleur away from the spokes it will actually help when using the 53 big ring. But as you know, you should not be cross-chaining big to big (or small to small).