OP, how often do you pedal when riding standing up? The whole trip or do you coast most of the time?

Pedaling while standing up uses more energy than sitting down. That's why its used mainly for sprinting or gaining speed when already in motion. I was forced to stand up for 3 miles before because my seat post clamp broke and had to ride it standing up to the nearest bike shop. I'll have to say that I did not pedal the whole way because it was hard even when I'm not sprinting. I can't imagine doing this for 10 miles or more.

Long term problems when pedaling the whole trip, quicker muscle degeneration, maybe, because you are redlining all the time. Coasting, not so much long term issues.