First to recommend the Marathon Plus. Have no experience w/t Supremes so I can't really comment on them. However, all my bikes have Marathon Plus' in different sizes. Over 16.000 combined mileage in 2.5 years w/one slow leak and one flat. It was a 2" self starting screw that nothing short of airless would've stopped. They are difficult to mount initially, but once they seat they're easy to get on and off w/good tire levers.