I have personally used a lot of different commuting / city / touring tires over the last few years. Kenda Kwest, Continental Contact, Specialized Infinity, Bontrager Sattelite Plus, and a bootload of Schwalbe:

I've owned and used just about every Schwalbe Marathon they make, except the new "expedition" tires like the extreme. Have also used the Big Apple and Kojak. Out of them all, the Supreme was my favourite of the lot. Neither the plus nor the supreme ever gave any trouble with flats, but the Supreme is a nice riding tire with great weight for its protection, whereas the plus is very protective, but chunky and I find it a bit harsh. The Plus was definitely the tire of choice for my cargo bike, but for a sportier ride i'd prefer the Supreme. This tire also has pretty good wet weather grip, in Edmonton I was using a 20" rear supreme with a 20" front marathon winter, and the supreme would hold grip well over wet roads and packed snow, only losing out to pure ice.