Thick tubes don't realy help. It just takes longer for the glass or wire stuck in the tire to wear its way through the tube. If you're getting frequent flats or just hate the idea of changing tubes on the road then either tire liners or tires with flat resistant kevlar belting in them help a lot. Contrary to what some here have found I only installed one set of liners one time and found them to be a proper PITA. But once the liners take a set to the tire I don't doubt that they are easier. A shop owner hates liners. He says he sees more flats from the edges cutting into the tube than flats from stuff that goes through the liner. So apparently careful placement of the liner and careful handling to ensure that the tube is not caught under the edge of the liner is needed. This means having lots of educated fingers when installing the tube and liner to ensure that all the stuff is in place. If you don't change out flat tubes a lot then you may find it's awkward to do all this at the same time. In that case either just live with the need to swap out the tubes from the occasional flat or look at buying kevlar belted flat resistant tires.