I have the C2s and they've been good to me. I used them as "bumpers" in my bike case just now (flew with 2 pairs of wheels plus bike in a soft case, with the wheels cushioning the frame) and they're fine. The Jet6 and Jet9 on the other side of the bike came through fine too. This is the third time I flew with the Bastognes in the same case, but the first time with two pairs of wheels.
C2s allow you to use much lower air pressure but I personally found that I prefer slightly higher pressure than their recommended 90 psi or so. I run maybe 100-105 psi. With normal rims I'd run 105-110 psi. I imagine that mixing wide and regular width rims could be a bit less consistent in feel - one tire softer, one harder.
I like the wide rims because you can run lower pressures for regular riding. For racing (hard cornering) I'm too old school and have not been able to adapt to lower pressures.
As far as durability they seem to be working fine for me after about 1 year of pretty regular use.
I can't speak for the non-C2 rims.
I was about 160 lbs, 5'7", and am reasonably kind to my wheels. Broken spokes are broken spokes though (related more to tension, metal quality, and build design/quality), and I've managed to break a few spokes in a few decades.
cdr