Main issue is that the hub is set up for straight-pull spokes(no j-bend). I haven't been able to figure out a way to get a j-bent spoke to engage the hub in a way that I'd be ready to trust long term.
I have an earlier version of Ksyriums, and they'd happily take generic straight-pull spokes, but I can't tell for sure if they'd fit yours. You'd might have to fit spoke washers to widen the head or some other kludge.
Obviously, if you manage to reliably anchor regular (straight pull) spokes, you're then free to use whatever rim and spoke nipples you can come up with. Rims don't care much what hub they're laced to, as long as you get the required spoke tension.